Table 3 Values of the parameters needed to determine the infinitesimal generator (Q) using 4 normal cell lines, where \(d_{i} = 1- \sum _{j=1}^{N} \left (p_{{ij}}^{+} + p_{{ij}}^{-}\right)\)
Translation (\(\lambda _{i}^{+}\)) | Degradation (\(\lambda _{i}^{-}\)) | μi | di | ||
CEBPA | 4 | 1.18489 | 3 | 0.333 | |
E2F1 | 4 | 1.79118 | 3 | 0.333 | |
FOXM1 | 4 | 2.78510 | 2 | 0.5 | |
c-MYC | 5 | 6.70809 | 3 | 0.333 | |
hTERT | 5 | 6.07682 | 1 | 1 | |
Normal: Activation/transcription processes (\(p_{{ij}}^{+}\)) | |||||
CEBPA | E2F1 | FOXM1 | c-MYC | hTERT | |
CEBPA | 0 | 0 | 0 | 0 | 0 |
E2F1 | 0 | 0 | 0 | 0.333 | 0 |
FOXM1 | 0 | 0 | 0 | 0.5 | 0 |
c-MYC | 0 | 0 | 0 | 0 | 0.333 |
hTERT | 0 | 0 | 0 | 0 | 0 |
Normal: Repression process (\(p_{{ij}}^{-}\)) | |||||
CEBPA | E2F1 | FOXM1 | c-MYC | hTERT | |
CEBPA | 0 | 0.333 | 0.333 | 0 | 0 |
E2F1 | 0 | 0 | 0 | 0 | 0.333 |
FOXM1 | 0 | 0 | 0 | 0 | 0 |
c-MYC | 0.333 | 0 | 0 | 0 | 0 |
hTERT | 0 | 0 | 0 | 0 | 0 |