Fig. 5

Correlation between gut microbes, TMA-synthesis enzymes, functions and precursors of TMAO production in AF patients. Interrelationship for the TMA-forming potential of microbial communities. Visual presentation of the correlation network based on spearman correlation analysis shows the gut microbes significantly associated with certain TMA-synthesis enzymes, which link to corresponding bacterial functional modules to transform the TMA precursors and participate in the formation of TMAO in AF patients. Red, positive correlation; blue, negative correlation; with statistical significance at FDR corrected p < 0.05 and correlation at |r|>0.4, where asterisk marked in boldface means correlation at |r| > 0.6