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Table 2 Top 30 enriched gene ontology terms for transcription start sites that are upregulated upon primary Schwann cell differentiation, ranked by fold enrichment. Beneath each term is a list of the genes that contributed to the term’s enrichment

From: SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells

Gene Ontology Term Fold Enrichment FDR-Corrected P-Value
Isopentenyl diphosphate biosynthetic process (GO:0009240) 36.73 1.56E-02
Idi1, Pmvk, Mvk
Isopentenyl diphosphate metabolic process (GO:0046490) 36.73 1.55E-02
Idi1, Pmvk, Mvk
Ribosomal small subunit export from nucleus (GO:0000056) 26.23 2.99E-02
Ran, Rps15, Npm1
Cholesterol biosynthetic process (GO:0006695) 17.49 1.55E-08
Insig1, Hds17b7, Hmgcr, Msmo1, Hmgcs1, Idi1, Pmvk, Tm7sf2, Fdft1, Mvk, Acly, Sc5d
Secondary alcohol biosynthetic process (GO:1902653) 17.08 1.87E-08
Insig1, Hsd17b7, Hmgcr, Msmo1, Hmgcs1, Idi1, Pmvk, Tm7sf2, Fdft1, Mvk, Acly, Sc5d
SRP-dependent cotranslational protein targeting to membrane (GO:0006614) 17.04 2.45E-19
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Coenzyme A metabolic process (GO:0015936) 16.32 1.52E-02
Hmgcr, Mccc2, Coasy, Acly
Cotranslational protein targeting to membrane (GO:0006613) 16.2 5.64E-19
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Ribosomal small subunit assembly (GO:0000028) 15.3 3.80E-03
Rps15, Rps10, Rps5, Rps14, Rps27l
Sterol biosynthetic process (GO:0016126) 15.3 4.86E-08
Insig1, Hsd17b7, Hmgcr, Msmo1, Hmgcs1, Idi1, Pmvk, Tm7sf2, Fdft1, Mvk, Acly, Sc5d
Protein targeting to ER (GO:0045047) 15.02 2.04E-18
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Viral transcription (GO:0019083) 14.9 5.06E-19
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Seh1l, Rpl5
Establishment of protein localization to endoplasmic reticulum (GO:0072599) 14.5 3.04E-18
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Regulation of cholesterol biosynthetic process (GO:0045540) 14.24 2.22E-06
Ran, Hmgcr, Hmgcs1, Idi1, Nfya, Pmvk, Tm7sf2, Fdft1, Mvk, Sc5d
Regulation of sterol biosynthetic process (GO:0106118) 14.24 2.19E-06
Ran, Hmgcr, Hmgcs1, Idi1, Nfya, Pmvk, Tm7sf2, Fdft1, Mvk, Sc5d
Viral gene expression (GO:0019080) 14.24 2.34E-19
Rpl18a, Rps15, Rpl9, Pcbp2, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, E1f3f, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Seh1l, Rpl5
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) 13.77 7.89E-18
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Isoprenoid biosynthetic process (GO:0008299) 13.12 1.47E-03
Hmgcr, Hmgcs1, Idi1, Pmvk, Mvk
Translational initiation (GO:0006413) 13 2.20E-19
Eif2b4, Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Eif4b, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Eif3f, Rpl3, Rps27a, Eif1b, Rps13, Rpl7, Rps26, Rplp0
Protein localization to endoplasmic reticulum (GO:0070972) 12.96 1.83E-18
Insig1, Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Bcap29, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Myelin assembly (GO:0032288) 12.89 2.98E-02
Ncmap, Cd9, Mtmr2, Pmp22
Nucleotide-excision repair, DNA duplex unwinding (GO:0000717) 11.13 4.41E-02
Uba52, Rps27a, Gtf2h1, Ddb1
Regulation of cholesterol metabolic process (GO:0090181) 10.93 1.50E-05
Ran, Hmgcr, Hmgcs1, Idi1, Nfya, Pmvk, Tm7sf2, Fdft1, Mvk, Sc5d
Protein targeting to membrane (GO:0006612) 10.65 4.14E-16
Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rab8b, Rpl23a, Pmp22, Rpl17, Rpl11, Aldh3a2, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5
Glucose 6-phosphate metabolic process (GO:0051156) 10.65 4.94E-02
G6pc3, Taldo1, Pgls, Gpi
Myelination (GO:0042552) 10.59 4.51E-10
Eif2b4, Mbp, Lpar1, Bcas1, Serinc5, Lgi4, Ncmap, Pllp, Egr2, Mpz, Id4, Acer3, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal
Ensheathment of neurons (GO:0007272) 10.39 5.84E-10
Eif2b4, Mbp, Lpar1, Bcas1, Serinc5, Lgi4, Ncmap, Pllp, Egr2, Mpz, Id4, Acer3, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal
Axon ensheathment (GO:0008366) 10.39 5.70E-10
Eif2b4, Mbp, Lpar1, Bcas1, Serinc5, Lgi4, Ncmap, Pllp, Egr2, Mpz, Id4, Acer3, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal
Ribosome assembly (GO:0042255) 10.05 8.16E-06
Rps15, Rps10, Rpl23a, Rpl11, Rps5, Rps14, Rps27l, Npm1, Rpl3, Rplp0, Rpl5
Cytoplasmic translation (GO:0002181) 9.62 1.17E-05
Rpl18a, Rpl9, Rpl29, Eif4b, Rpl17, Rpl11, Rpl26, Rpl18, Eif3f, Rps26, Rplp0