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Table 3 Top 30 enriched gene ontology terms for transcription start sites that are downregulated upon primary Schwann cell differentiation, ranked by fold enrichment. Beneath each term is a list of the genes that contributed to the term’s enrichment

From: SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells

Gene Ontology Term Fold Enrichment FDR-Corrected P-Value
Vesicle transport along actin filament (GO:0030050) 33.96 2.44E-02
 Wasl, Fnbp1l, Actn4
Regulation of protein folding (GO:1903332) 22.64 8.45E-03
Bag5, Dnajb2, Sgtb, St13
Activation of MAPKKK activity (GO:0000185) 20.58 1.08E-02
Traf7, Gadd45b, Gadd45a, Gadd45g
Response to laminar fluid shear stress (GO:0034616) 18.86 2.87E-03
Klf2, Xbp1, Nfe2l2, Ets1, Adam9
Establishment of protein localization to mitochondrial membrane (GO:0090151) 13.32 3.33E-02
Hsp90aa1, Tomm22, Timm10
Membrane protein intracellular domain proteolysis (GO:0031293) 12.58 3.83E-02
Aph1a, Traf6, Aph1b, Ngfr
Membrane protein proteolysis (GO:0033619) 10.71 1.80E-03
Aph1a, Traf6, Aph1b, Adam19, Ngfr, Ctsh, Adam9
Response to fluid shear stress (GO:0034405) 9.99 7.03E-03
Klf2, Xbp1, Cited2, Nfe2l2, Ets1, Adam9
Multivesicular body sorting pathway (GO:0071985) 8.84 3.32E-02
Rubcn, Vps25, Vps28, Vps4b, Chmp3
Positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:0036003) 8.84 3.30E-02
Klf2, Xbp1, Nfe2l2, Atf4, Ddit3
Interleukin-12-mediated signaling pathway (GO:0035722) 8.61 4.59E-03
P4hb, Capza1, Hnrnpdl, Cfl1, Rala, Rplp0, Pak2
Cortical actin cytoskeleton organization (GO:0030866) 8.49 1.36E-02
Calr, Cavin3, Arf6, Tln1, Ehd2
Cellular response to interleukin-12 (GO:0071349) 8.25 5.46E-03
P4hb, Capza1, Hnrnpdl, Cfl1, Rala, Rplp0, Pak2
Response to interleukin-12 (GO:0070671) 8.08 6.06E-03
P4hb, Capza1, Hnrnpdl, Cfl1, Rala, Rplp0, Pak2
ER-nucleus signaling pathway (GO:0006984) 7.86 4.74E-02
Calr, Xbp1, Nfe2l2, Atf4, Ddit3
Cortical cytoskeleton organization (GO:0030865) 7.55 2.25E-02
Calr, Cavin3, Arf6, Rhoc, Tln1, Ehd2
Response to epidermal growth factor (GO:0070849) 6.93 3.03E-02
Tpr, Col1a1, Gstp1, Zfp36, Snai2, Mars
Response to unfolded protein (GO:0006986) 6.41 2.32E-06
Hspb2, Hsp90aa1, Dnajb2, Calr, Serpinh1, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Tmem129, Ddit3, Tln1, Bag3, Optn
Endoplasmic reticulum unfolded protein response (GO:0030968) 6.23 8.34E-04
Calr, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Ddit3, Tln1
Negative regulation of intracellular transport (GO:0032387) 6.19 2.13E-02
Cryab, Derl2, Tpr, Itgb1bp1, Map 1b, Bag3, Snx12
IRE1-mediated unfolded protein response (GO:0036498) 6.17 4.57E-02
Dnajb11, Xbp1, Arfgap1, Fkbp14, Syvn1, Tln1
Cellular response to unfolded protein (GO:0034620) 6.03 2.09E-04
Calr, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Ddit3, Tln1, Bag3, Optn
Intracellular steroid hormone receptor signaling pathway (GO:0030518) 5.74 2.91E-02
Tada3, Calr, Ddx5, Ywhah, Ube3a, Nedd4, Plpp1
Response to topologically incorrect protein (GO:0035966) 5.6 9.46E-06
Hspb2, Hsp90aa1, Dnajb2, Calr, Serpinh1, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Tmem129, Ddit3, Tln1, Bag3, Optn
Positive regulation of axonogenesis (GO:0050772) 5.33 2.01E-02
Chd2, Map 2k1, Arhgdia, Tnfrsf12a, Eif4g2, Ngfr, Map 1b, Stk25
Regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) 5.23 2.69E-03
Klf2, Jun, Psmd8, Xbp1, Cited2, Nfe2l2, Atf4, Ddit3, Bag3, Nedd4, Higd1a
Cellular response to topologically incorrect protein (GO:0035967) 5.14 8.06E-04
Calr, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Ddit3, Tln1, Bag3, Optn
Cell redox homeostasis (GO:0045454) 5.14 4.57E-02
Nnt, P4hb, Pdia3, Prdx1, Nfe2l2, Nqo1, Ddit3, Tmx1
Endosome organization (GO:0007032) 5.14 4.55E-02
Rab5b, Tmem127, Vps25, Vps28, Vps4b, Chmp3, Plekhj1
Rho protein signal transduction (GO:0007266) 5.08 4.76E-02
Arhgdia, Cdh13, Cfl1, Ngfr, Adgrg1, Cdc42ep3