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Table 4 Top 15 enriched gene ontology terms for transcription start sites that are downregulated upon loss of SOX10 in S16 cells, ranked by fold enrichment. Beneath each term is a list of the genes that contributed to the term’s enrichment

From: SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells

Gene Ontology Term Fold Enrichment FDR-Corrected P-Value
Regulation of myelination (GO:0031641) 17.54 1.41E-02
Sox10, Lgi4, Mag, Ctsc, S100b, Mtmr2
Myelination (GO:0042552) 15.35 1.86E-07
Mbp, Lpar1, Sox10, Bcas1, Serinc5, Lgi4, Mpz, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal
Ensheathment of neurons (GO:0007272) 15.06 1.16E-07
Mbp, Lpar1, Sox10, Bcas1, Serinc5, Lgi4, Mpz, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal
Axon ensheathment (GO:0008366) 15.06 7.73E-08
Mbp, Lpar1, Sox10, Bcas1, Serinc5, Lgi4, Mpz, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal
Substantia nigra development (GO:0021762) 13.35 3.88E-02
Mbp, Ndrg2, Mag, Cnp, Ldha
Gliogenesis (GO:0042063) 7.53 1.51E-04
Lpar1, Sox10, Lgi4, Lamb1, Erbb3, App, Srgap2, Cd9, Adgrg1, Metrn, Mag, Cnp, S100b
Glial cell differentiation (GO:0010001) 7.44 2.38E-03
Lpar1, Sox10, Lgi4, Erbb3, App, Cd9, Metrn, Mag, Cnp, S100b
Regulation of supramolecular fiber organization (GO:1902903) 4.84 2.53E-03
Capg, Lpar1, Nav3, Mid1ip1, Arl2, Chadl, Tmsb10, Cryab, Arpc1a, App, Limch1, Sorbs3, Emilin1, S100a10
Extracellular structure organization (GO:0043062) 3.87 4.98E-02
Lamb1, App, Col16a1, Itga6, Itgb8, Vwa1, Emilin1, Col6a1, Jam3, Col9a3, Ddr1
Biological adhesion (GO:0022610) 3.19 1.60E-03
Lrrc4b, Cd81, Lamb1, Il1rap, Gldn, App, Col16a1, Mpz, Hepacam, Itga6, Srgap2, Clic1, Itgb8, Ttyh1, Ctnna3, Cd9, Sorbs3, Adgrg1, Emilin1, Mag, Cnn3, Col6a1, Jam3, Ddr1
Cell adhesion (GO:0007155) 3.07 2.72E-03
Lrrc4b, Lamb1, Il1rap, Gldn, App, Col16a1, Mpz, Hepacam, Itga6, Srgap2, Clic1, Itgb8, Ttyh1, Ctnna3, Cd9, Sorbs3, Adgrg1, Emilin1, Mag, Cnn3, Col6a1, Jam3, Ddr1
Neuron development (GO:0048666) 2.9 2.82E-02
Sema3b, Lgi4, Lamb1, Ahi1, Gldn, Gas7, App, Ngfr, Rps6ka5, Srgap2, Rab13, Ank3, Mag, Cnp, S100b, Jam3, Mtmr2, Dclk1, Sh3kbp1, Ddr1
Regulation of cellular component movement (GO:0051270) 2.79 1.48E-02
Sema3b, Lpar1, Cd81, Nav3, Tmsb10, Lamb1, Srgap2, Erbb3, App, Itga6, Srgap2, Limch1, Rassf4, Ctnna3, Cd9, Adgrg1, Emilin1, Tgfbr3, Jam3, Snai2, Gpsm3, Mal
Cytoskeleton organization (GO:0007010) 2.65 1.81E-02
Capg, Tacc2, Arl2, Tmsb10, Cryab, Epb41l2, Arpc1a, Mical3, Arhgap26, Shroom2, Gas7, Ccser2, Marcks, Srgap2, Limch1, Rab13, Sorbs3, Tacc1, Ank3, Cnn3, Cnp, Diaph3, Sh3kbp1, Tubb2a
Plasma membrane bounded cell projection organization (GO:0120036) 2.5 4.96E-02
Sema3b, Lpar1, Lamb1, Ahi1, Gldn, Gas7, App, Itga6, Ngfr, Rps6ka5, Srgap2, Ttyh1, Rab13, Ank3, Mag, Cnp, S100b, Ehd4, Jam3, Mtmr2, Dclk1, Sh3kbp1, Ddr1, Pmp22