Fig. 7
From: Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Endogenous, statin-treated, and statin-induced changes in OAS1 splicing by deQTL genotype in European ancestry subset. a OAS1 annotated isoforms. For three abundant splice isoforms with introns beginning at hg19 chr12:113355505 (p46:b-d, unnamed isoform: e-g, p48:h-j), the proportion of each isoform in control- and statin-treated European ancestry LCLs was calculated using junction-spanning read fractions. Isoform fractions in (B,E,H) control- and (C,F,I) statin-treated LCLs as well as the (D,G,J) statin-induced changes in these isoform fractions were plotted by European ancestry lead OAS1 deQTL (rs7134391) imputed genotypes in Tukey box and whisker plots. Since genotypes were imputed, some of the outlying points may be genotype assignment errors