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Table 1 Sequence variants in CDS of BCG-1 (Russia) parent seed lots 361, 367 and 368 and their progeny clinical isolates compared to the reference sequence BCG-1 (Russia) (GenBank: CP013741)

From: First insight into the whole-genome sequence variations in Mycobacterium bovis BCG-1 (Russia) vaccine seed lots and their progeny clinical isolates from children with BCG-induced adverse events

Parent gene BOVR Parent gene BOVR codon change Chain Seed lot 361 1986 2925 4159 5075 5340 5448 Seed lot 367 3363 Seed lot 368 577 1032 Parent gene BOVR amino acid change Product name Effect (putative impact)
01860 509delC CG CG CG CG CG CG CG CG C
1.0
CG CG CG Pro170fs thioesterase high
03020 121C > T C C C C C T
0.37
C C C C C C Ala41Thr PE-PGRS family protein PE_PGRS7 moderate
03865 685delA + CA CA CA CA CA CA CA CA CA C
0.69
C
0.47
CA Thr229fs methionine aminopeptidase high
06950 1403 T > C + T T T T T T T T T T C
0.43
T Leu468Ser ATP synthase subunit beta moderate
08645 2004A > G + G
0.42
A G
1.0
A A A A A A A A A Val668Val polyketide synthase low
08855 1115A > G G
0.18
A A A A A G
1.0
A A A A A Leu372Pro amino acid transporter moderate
09330 982G > A + A
0.40
G A
0.96
G G G A
1.0
G G G G G Ala328Thr type VII secretion integral membrane protein EccD moderate
09345 128 T > C + C
0.33
T C
1.0
T T T C
1.0
T T T T T Ile43Thr type VII secretion AAA-ATPase EccA moderate
10,325 634delC + GC GC GC GC GC GC GC GC GC GC GC G
0.28
Leu212fs universal stress protein UspA high
10,615 587C > T T
0.18
C T
1.0
C C C T
1.0
C C C C C Gly196Asp dolichol-phosphate mannosyltransferase moderate
12,050 78C > A A
0.29
C C C C C C C C C C C Leu26Leu ornithine aminotransferase low
13,820- 755C > T + T
0.54
C T
1.0
C C C T
0.89
C C C C C Ala252Val protease moderate
15,090 2139A > G G
1.0
G
1.0
G
1.0
G
1.0
G
1.0
G
1.0
G
1.0
G
1.0
G
1.0
G
0.25
G
0.46
G
1.0
Ala713Ala protein-PII uridylyltransferase low
16,925 846C > T C C C C C C C C C C C T
0.18
Leu282Leu N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase low
17,690 833A > G + A A A A A A A A G
1.0
A A A Gln278Arg amidase moderate
  1. Sequence variants are presented as the proportion of reads with alternative allele/all reads; del deletion, fs frameshift