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Fig. 5 | BMC Genomics

Fig. 5

From: Integrating binding and expression data to predict transcription factors combined function

Fig. 5

Predicted functions of YY1 and YY2 on specific and shared targets in HeLa cells. The target analysis was applied using two sets of data from the HeLa cells: expression data in YY1- and YY2-knockdown cells (GSE14964) and two sets of ChIP peaks using antibodies for YY1 (GSE31417) and YY2 (GSE96878). Predicted targets were ranked based on the distance of their peaks to the transcription start sites (TSS) and their fold-change. The empirical cumulative distribution function (ECDF) of the regulatory potential of each group of targets (Down, None or Up-regulated genes) of a YY1 and b YY2 was calculated. c The shared targets were ranked based on the distance of their peaks to the TSS in which they had overlapping peaks and the product of the corresponding fold-changes. The ECDF of the regulatory potential of each group of targets (Competitively, None or Cooperatively regulated genes) was calculated

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