Fig. 1
From: Circular DNA intermediates in the generation of large human segmental duplications
Specific A-B/C-D to B-A/D-C flip in sequence indicative of duplications generated by circular intermediates. A Scheme showing the specific change in sequence order in duplications generated via a circular DNA intermediate with unique and distinct closing and opening points. Note that the ends of the ancestral locus A and D will appear joined together inside the derivative duplication A/D. Likewise, the ends of de derivative duplication will appear joined together in the ancestral locus B/C. Duplicated sequences are represented by boxes of the same color: A-B (green boxes) and C-D (blue boxes). B Corresponding homology plot of the above duplicated segments showing the specific two parallel identity slant lines produced by the specific flip in block sequence order-