Fig. 1

RRHO map showing highly significant overlap between human islet RNA-seq and INS-1E cell transcriptomes (a) and between microarrays and proteome of INS-1E cells following palmitate exposure (b). RNA-seq in human islets, microarrays in INS-1E cells and proteome in INS-1E cells were performed after exposure to palmitate for 48 h, 14 h and 24 h, respectively. Genes are ranked by fold change from most up- to most down-regulated. The level map colors represent -log p-values for overlap between ranked genes, with an indication of the smallest FDR corrected p-value for coordinates with the most statistically significant overlap between genes up-regulated in both datasets (bottom left corner) and down-regulated in both (top right corner)