Fig. 5

Network inference analysis of palmitate-modified genes/proteins. Enriched regulators identified by IPA and DAVID were added to the 207 differentially expressed genes, resulting in a dataset of 258 genes considered for this analysis. Upregulated genes are shown in red, downregulated genes in green, and the added regulators are shown in white circles. Regulatory networks were inferred in the RNA-seq and proteomics data separately using a random forest algorithm to score predictors and then the 2 networks were combined. Blue lines denote regulations identified in RNA-seq, yellow lines denote regulations identified in proteomics and black lines denote regulations found in both datasets. Regulations present in biological databases (IPA, DAVID, TRANSFAC, RegNetwork) are shown in continuous lines and regulations that have not been previously described are shown in dashed lines