Fig. 4

a The conserved proteasome core complex identified by ClusterM. Yeast, human, fly, and worm proteins are shown in light blue, green, pink and purple, respectively. Gray dotted lines indicate protein sequence similarity and blue solid lines represent protein-protein interactions. b The conserved spliceosomal complex identified by ClusterM. Yeast, human, fly, and worm proteins are shown in light blue, green, pink and purple, respectively. Gray dotted lines indicate protein sequence similarity and blue solid lines represent protein-protein interactions. Red solid lines are PPIs in STRING database