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Table 2 KEGG functional annotation of overall differentially expressed genes of selected tissues with the largest number of genes averaged across two cows in the Main Cows dataset

From: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

Tissues

Enrichment

No. of genes (Overlap NuMPa)

Adj. p

Other pathways

Heart

Oxidative phosphorylation

101 (93)

3.3e−53

Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, NAFLD, carbon metabolism, Metabolic pathways, cardiac muscle contraction, TCA cycle,

Leg muscle

Oxidative phosphorylation

83 (38)

1.0e−32

Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Carbon metabolism, metabolic pathways, Proteasome, cardiac muscle contractionBiosynthesis of antibiotics

Loin muscle

Oxidative phosphorylation

89 (86)

5.8e− 39

Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Huntington’s disease, carbon metabolism, Proteosome, Cardiac muscle contraction

Rib muscle

Oxidative phosphorylation

86 (39)

1.8e−35

Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Metabolic pathways, carbon metabolism, Proteasome

Tongue

Oxidative phosphorylation

98 (91)

3.0e−50

Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Metabolic pathways, carbon metabolism, cardiac muscle contraction,

Kidney cortex

Metabolic pathways

312 (118)

3.9e−28

Biosynthesis of antibiotics, Carbon metabolism, Valine, leucine and isoleucine degradation, Glycine, serine and threonine metabolism, tryptophane metabolism, Fatty acid metabolism

Kidney medulla

Focal adhesion

67 (0)

3.0e−10

Tight junction, calcium signalling pathway, Gastric acid secretion. ECM-receptor interaction, cGMP-PKG signalling pathway, Gastric acid secretion, Dilated cardiomyopathy

Liver

Metabolic pathways

387 (123)

4.1e−49

Biosynthesis of antibiotics, Peroxisome, valine, leucine and isoleucine degradation, complement and coagulation cascades, fatty acid degradation, tryptophan metabolism, carbon metabolism

Brain caudal lobe

Axon guidance

57 (0)

8.0e−18

Glutamatergic Synapse, Domaminergic synapse, MAPK signalling pathway, Adrenergic signalling in cardiomyocytes, Retrograde endocannabinoid signalling, cAMP signalling pathway, Synaptic vesicle cycle, GABAergic synapse, Morphine addiction, Glutamatergic synapse, Circadian entrainment, Dopaminergic synapse

Brain cerebellum

Glutamatergic synapse

49 (2)

3.1e− 14

GABAergic synapse, Retrograde endocannabinoid signalling, Morphine addiction, Circadian entrainment, Dopaminergic synapse, cAMP signalling pathway, Adrenergic signalling in cardiomyocytes, axon guidance,

Brain stem

GABAergic synapse

36 (2)

3.1e− 9

Glutamergic synapse, Morphine addiction, Retrograde endocannabinoid signalling, Dopaminergic synapse, Circadian entrainment

Leukocytes

Chemokine signalling pathways

74

4.7e−15

Focal adhesion, leukocyte transendothelial migration, Rap1 signalling pathway, natural killer cell mediated cytotoxicity, regulation of actin cytoskeleton, B cell receptor signalling pathway

  1. awe show the number of genes in the top enriched pathway that overlap mitochondrial proteins