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Table 2 KEGG functional annotation of overall differentially expressed genes of selected tissues with the largest number of genes averaged across two cows in the Main Cows dataset

From: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

Tissues Enrichment No. of genes (Overlap NuMPa) Adj. p Other pathways
Heart Oxidative phosphorylation 101 (93) 3.3e−53 Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, NAFLD, carbon metabolism, Metabolic pathways, cardiac muscle contraction, TCA cycle,
Leg muscle Oxidative phosphorylation 83 (38) 1.0e−32 Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Carbon metabolism, metabolic pathways, Proteasome, cardiac muscle contractionBiosynthesis of antibiotics
Loin muscle Oxidative phosphorylation 89 (86) 5.8e− 39 Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Huntington’s disease, carbon metabolism, Proteosome, Cardiac muscle contraction
Rib muscle Oxidative phosphorylation 86 (39) 1.8e−35 Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Metabolic pathways, carbon metabolism, Proteasome
Tongue Oxidative phosphorylation 98 (91) 3.0e−50 Parkinson’s disease, Alzheimer’s disease, NAFLD, Huntington’s disease, Metabolic pathways, carbon metabolism, cardiac muscle contraction,
Kidney cortex Metabolic pathways 312 (118) 3.9e−28 Biosynthesis of antibiotics, Carbon metabolism, Valine, leucine and isoleucine degradation, Glycine, serine and threonine metabolism, tryptophane metabolism, Fatty acid metabolism
Kidney medulla Focal adhesion 67 (0) 3.0e−10 Tight junction, calcium signalling pathway, Gastric acid secretion. ECM-receptor interaction, cGMP-PKG signalling pathway, Gastric acid secretion, Dilated cardiomyopathy
Liver Metabolic pathways 387 (123) 4.1e−49 Biosynthesis of antibiotics, Peroxisome, valine, leucine and isoleucine degradation, complement and coagulation cascades, fatty acid degradation, tryptophan metabolism, carbon metabolism
Brain caudal lobe Axon guidance 57 (0) 8.0e−18 Glutamatergic Synapse, Domaminergic synapse, MAPK signalling pathway, Adrenergic signalling in cardiomyocytes, Retrograde endocannabinoid signalling, cAMP signalling pathway, Synaptic vesicle cycle, GABAergic synapse, Morphine addiction, Glutamatergic synapse, Circadian entrainment, Dopaminergic synapse
Brain cerebellum Glutamatergic synapse 49 (2) 3.1e− 14 GABAergic synapse, Retrograde endocannabinoid signalling, Morphine addiction, Circadian entrainment, Dopaminergic synapse, cAMP signalling pathway, Adrenergic signalling in cardiomyocytes, axon guidance,
Brain stem GABAergic synapse 36 (2) 3.1e− 9 Glutamergic synapse, Morphine addiction, Retrograde endocannabinoid signalling, Dopaminergic synapse, Circadian entrainment
Leukocytes Chemokine signalling pathways 74 4.7e−15 Focal adhesion, leukocyte transendothelial migration, Rap1 signalling pathway, natural killer cell mediated cytotoxicity, regulation of actin cytoskeleton, B cell receptor signalling pathway
  1. awe show the number of genes in the top enriched pathway that overlap mitochondrial proteins