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Table 3 Summary of gene, composition, and functional enrichment of KEGG pathways of genes in co-expression clusters (FDR <1e-05) in the Main Cows dataset

From: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

Cluster No. of MtMP genes No. of NuMP
No. of Non-MP genes Total No. of genes Enrichment of pathways
13 216 584 813 Parkinson’s disease, Oxidative phosphorylation,
Alzheimer’s diseases, Huntington diseases, Non-alcohol fatty liver diseases, metabolic pathways, Citrate cycle, carbon metabolism, Cardiac muscle contraction, Proteosome
II 0 10 871 881 Retrograde endocannabinoid signaling,
GABAergic synapse, Nicotine addiction, Morphine addictions, Glutamatergic synapse,
Dopaminergic synapse, Synaptic vesicle cycle, Neuroactive ligand-receptor interaction
III 0 12 923 935 Cell adhesion molecules (CAMs), Staphylococcus aureus infection, intestinal immune network for IgA production, Leishmaniasis, Antigen processing and presentation, viral myocarditis, Allograft rejection, primary immunodeficiency, Hematopioetic cell lineage, Natural killer cell-mediated cytotoxicity
(NuMP cluster)
0 79 466 545 Chemical carcinogenesis,
Complement and coagulation cascade, Drug metabolism – cytochrome p450 metabolism, steroid hormone biosynthesis, retinol metabolism, Metabolic pathways, Complement and coagulation cascades, bile secretion, primary bile acid biosynthesis, tryptophan metabolism, carbon metabolism, fatty acid metabolism