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Fig. 4 | BMC Genomics

Fig. 4

From: Leishmania infection induces a limited differential gene expression in the sand fly midgut

Fig. 4

DE transcripts sorted by molecular functions. a-b. Heatmaps and cluster analyses depicting differences in the number of DE genes up-regulated (a) and down-regulated (b) by Leishmania infection belonging to different groups of molecular function. Legends: Cs: cytoskeleton; Detox: oxidative metabolism/detoxification; Extmat: extracellular matrix; Imm: immunity; Met: metabolism; Ne: nuclear export; Nr: nuclear regulation; Pe: protein export; Pm: protein modification; Prot: proteosome machinery; Ps: protein synthesis machinery; S: secreted protein; St: signal transduction; Storage: storage protein; Te: transposable element; Tf: transcription factor; Tm: transcription machinery; Tr: transporters and channels; Uk: unknown protein. c-d. Heatmaps and cluster analyses depicting differences in the number of DE genes up-regulated (c) and down-regulated (d) by Leishmania infection, belonging to different sorts of oxidative metabolism/detoxification molecular function. Legends: Dehyd: dehydrogenase; Glutat: glutathione s-transferase; P450: cytochrome P450; Oxidase: oxidase/peroxidase; Reduc: reductase; Abc: Transporter ABC superfamily; Thio: thioredoxin binding protein; Transf: sulfotransferase. e-f. Heatmaps and cluster analyses depicting differences in the number of DE genes up-regulated (e) and down-regulated (f) by Leishmania infection belonging to different sorts of metabolism molecular function, respectively. Legends: Aa: amino acid metabolism; Carb: carbohydrate metabolism; Energy: energy production; Int: intermediate metabolism; Lipd: lipid metabolism; Nuc: nucleotide metabolism. g-h. Heatmaps and cluster analyses depicting differences in the number of DE genes up-regulated (g) and down-regulated (h) belonging to different sorts of secreted protein molecular function. The heatmaps are color-coded according to the legends on the right. Legends: S: other; Metal: metalloprotease; Lipoc: lipocalin; Met-li: lipase; Met-nu: nuclease; Mucin; Protea: protease; Protin: protease inhibitor; Uk: unknown protein. DE was considered significant for transcripts displaying LFC either lower than − 1 or higher than 1 and FDR q-value lower than 0.05

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