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Fig. 5 | BMC Genomics

Fig. 5

From: Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats

Fig. 5

Gene-vocalization links. MeCyan gene module is the most positively correlated module with all female rat acoustic properties. ENRICHR gene enrichment software was used to examine gene pathways within this module, as presented here. Data were plotted using weight as a factor using Cytoscape 3.3.0 software. The most significant connections are plotted using weight as a factor; lines represent significant correlations between genes. Colors are indicative of the same enriched pathway: Dark purple (monoamine transmembrane transporter activity; dopamine transmembrane transporter activity; indolalkylamine metabolic process): Slc6a4, Ddc, Tph2; Light yellow (nervous system development, axon guidance/axonogenesis): Gss, Gfra1, Sim1, Scg1; Brown (RNA splicing; mRNA processing; peptidyl-prolyl cis-trans isomerase activity): Ppil3, Fkbp14, Wbp11, Magohb; Light Purple (neuron migration, axon guidance; generation of neurons and depolarization): Sema3a, Ndnf, Runx2, Smad7, Gja5, Rangrf; Light Pink (neuropeptide, cell signaling; transcription): Pax8, Pax5, Nts

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