Skip to main content

Table 1 Example of directional overlap with human PD datasets. Grey text is associated with non-significant p values

From: Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats

Current Rat Data Set Human Data Sets Adjusted p value Overlapping Gene List
Female, downregulated Parkinson’s disease
CNS: downregulated GSE19587 [34]
Region: inferior olivary nucleus
Sex: Males and females
Subjects: PD vs Control
0.00030 Rpl30; Rpl21; Plekhb1; Gdf1; Hsd17b4; Adipor2; Tf; Tspan8; Kif5c; Sgk1; Rps27a; Cryab; Rps24
PARK7 knockdown
Peripheral: downregulated
GSE5519 [39]
DJ-1 cell lines: H157 non-small-cell lung carcinoma cells
0.020 Hsp90aa1; Rpl21; Psmd14; Pih1d1; Pomp; Hspe1; Cox5a; Tomm20; Cox6b1; Hspd1; Mob4; Dnaja1; Efr3a; Psma4; Ugp2; Tomm7; Uqcrfs1; Rps24; BIrc2; Chmp5
Female, upregulated Parkinson’s disease
CNS: upregulated
GSE7621 [40]
Region: Substantia nigra
Sex: Males and Females
Subjects: PD vs normal control
0.00039 Tiam1; Tcf7l2; Gja1; Ddit4; Clstn1; Irs2; Actb; Scn1b
PARK2 knockdown
Tumor cells: upregulated
GSE50864 [41]
Glioma cell lines: SNB19 and SF539
0.00012 Gja1; Ednrb; Atxn1; Temn4; Col5a1; Ctnnd2; Lrp4; Cd59; Megf8; Mylk
Male, downregulated Parkinson’s disease
CNS: downregulated GSE19587 [42]
Region: inferior olivary nucleus
Sex: Males and females
Subjects: PD vs Control
0.061 Eef1a1; Slc14a1; Tuba1c; Tf; Sparc; Rps3a; Sgk1; S100b; B2m; Ppia; Gfap
PARK7 knockdown
CNS: downregulated
GSE17204 [43]
DJ-1 silenced neuroblastoma vs control cells
0.019 Gpr37; Sema3c; Stxbp1; F2r; Lrp4; Atp1a3; Esrrg; Abcc10; Lamp5; Qdpr; Trim9; C7; Dpysl3; Anxa6; Spock1; Spry1; Pfkm
Male, upregulated Parkinson’s disease
CNS: Upregulated
GSE7621 [34]
Region: inferior olivary nucleus
Sex: Males and females
Subjects: PD vs Control
1.0 Qdpr; Cdkn1b; Slc24a3; Usp54; Atp1a3; Spock1; Stom; Rpl23a; Sh3gl2; Pvalb
Park7 knockdown
CNS: downregulated
GSE17204 [43]
DJ-1 silenced neuroblastoma vs control cells
0.12 Dhfr; Nfasc; Pgbd5; Epas1; Atp1a3; Stmn4; Slc27a2