Table 1 Example of directional overlap with human PD datasets. Grey text is associated with non-significant p values
Current Rat Data Set | Human Data Sets | Adjusted p value | Overlapping Gene List |
|---|---|---|---|
Female, downregulated | Parkinson’s disease CNS: downregulated GSE19587 [34] Region: inferior olivary nucleus Sex: Males and females Subjects: PD vs Control | 0.00030 | Rpl30; Rpl21; Plekhb1; Gdf1; Hsd17b4; Adipor2; Tf; Tspan8; Kif5c; Sgk1; Rps27a; Cryab; Rps24 |
PARK7 knockdown Peripheral: downregulated GSE5519 [39] DJ-1 cell lines: H157 non-small-cell lung carcinoma cells | 0.020 | Hsp90aa1; Rpl21; Psmd14; Pih1d1; Pomp; Hspe1; Cox5a; Tomm20; Cox6b1; Hspd1; Mob4; Dnaja1; Efr3a; Psma4; Ugp2; Tomm7; Uqcrfs1; Rps24; BIrc2; Chmp5 | |
Female, upregulated | Parkinson’s disease CNS: upregulated GSE7621 [40] Region: Substantia nigra Sex: Males and Females Subjects: PD vs normal control | 0.00039 | Tiam1; Tcf7l2; Gja1; Ddit4; Clstn1; Irs2; Actb; Scn1b |
PARK2 knockdown Tumor cells: upregulated GSE50864 [41] Glioma cell lines: SNB19 and SF539 | 0.00012 | Gja1; Ednrb; Atxn1; Temn4; Col5a1; Ctnnd2; Lrp4; Cd59; Megf8; Mylk | |
Male, downregulated | Parkinson’s disease CNS: downregulated GSE19587 [42] Region: inferior olivary nucleus Sex: Males and females Subjects: PD vs Control | 0.061 | Eef1a1; Slc14a1; Tuba1c; Tf; Sparc; Rps3a; Sgk1; S100b; B2m; Ppia; Gfap |
PARK7 knockdown CNS: downregulated GSE17204 [43] DJ-1 silenced neuroblastoma vs control cells | 0.019 | Gpr37; Sema3c; Stxbp1; F2r; Lrp4; Atp1a3; Esrrg; Abcc10; Lamp5; Qdpr; Trim9; C7; Dpysl3; Anxa6; Spock1; Spry1; Pfkm | |
Male, upregulated | Parkinson’s disease CNS: Upregulated GSE7621 [34] Region: inferior olivary nucleus Sex: Males and females Subjects: PD vs Control | 1.0 | Qdpr; Cdkn1b; Slc24a3; Usp54; Atp1a3; Spock1; Stom; Rpl23a; Sh3gl2; Pvalb |
Park7 knockdown CNS: downregulated GSE17204 [43] DJ-1 silenced neuroblastoma vs control cells | 0.12 | Dhfr; Nfasc; Pgbd5; Epas1; Atp1a3; Stmn4; Slc27a2 |