Table 3 Significantly enriched canonical pathways in kidney and jejunum of sows fed diets containing low, medium, and high dietary P contents throughout gestation and lactation
Tissue | KEGG pathway | Number of annotated genes in the pathways | FDR-adjusted P-value | Involved genes |
|---|---|---|---|---|
Kidney | Metabolic pathways | 1388 | 1.38E-04 | GALT,ENTPD5,ACADVL,MAT2A, ACSL1,ACOX2,CBR1,MGLL, DGAT2,G6PC,GSTA1,ACSM4, ACAA1,ALDH3A1,CYP27B1, HAO1,FADS2,BDH1 |
PPAR signaling pathway | 75 | 2.68E-06 | CPT2,ACOX2,ACSL1,ACAA1, FABP3,FADS2,SLC27A2 | |
Protein processing in endoplasmic reticulum | 161 | 6.72E-03 | HSPA8,DNAJB1,DNAJA1,HSPH1, HSPA5 | |
Peroxisome | 84 | 5.78E-04 | ACOX2,HAO1,ACAA1,ACSL1, SLC27A2 | |
Fatty acid metabolism | 57 | 1.38E-04 | ACADVL,ACSL1,ACAA1,FADS2, CPT2 | |
Protein digestion and absorption | 86 | 6.72E-03 | COL3A1,SLC7A7,COL1A2,COL1A1 | |
Fatty acid degradation | 41 | 5.78E-04 | ACSL1,ACAA1,ACADVL,CPT2 | |
Metabolism of xenobiotics by cytochrome P450 | 49 | 1.20E-02 | ALDH3A1,CBR1,GSTA1 | |
Complement and coagulation cascades | 80 | 3.10E-02 | C1S,PLG,C7 | |
ECM-receptor interaction | 84 | 3.16E-02 | COL1A2,FN1,COL1A1 | |
Jejunum | Metabolic pathways | 1388 | 3.58E-03 | GALK1,B3GALT2,HMOX1,DHRS4,NT5E,XDH,IDUA,FUT2,PHOSPHO1,ADA,CHPF,SPR,PLA2G2D |
Viral protein interaction with cytokine and cytokine receptor | 84 | 4.38E-02 | CXCL9,CCL20,CXCL10 | |
IL-17 signaling pathway | 88 | 4.38E-02 | CCL20,MAPK6,CXCL10 |