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Table 1 Top 20 human genes linked to alcohol problems and epigenetics

From: SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol

Human gene

PubMed Citations

Worm Gene Expression

Alcohol problems

Epigenetics

Gene

Expression

STAT3

87

363

sta-1

Up

GSTP1

19

284

gst-16

Down

gst-39

Up

gst-38

Up

gst-19

Down

EP300

1

153

cbp-1

Down

NOTCH1

7

149

glp-1

Down

SLC6A4

193

123

snf-11

Up

CREBBP

6

123

cbp-1

Down

STAT1

26

113

sta-1

Up

TLR4

202

102

tol-1

Down

SFN

2

96

ftt-2

Up

VDR

7

95

nhr-8

Up

RHOA

7

62

rho-1

Down

TLR2

42

58

tol-1

Down

FRY

19

58

sax-2

Down

ABCB1

6

58

pgp-5

Up

AGO2

2

58

alg-2

Down

alg-5

Down

HNF4A

9

56

nhr-35

Up

nhr-60

Down

STAT4

4

45

sta-1

Up

RAC1

6

42

ced-10

Down

LMNA

2

41

ifd-2

Down

ifd-1

Up

KAT5

1

40

mys-4

Down