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Table 1 Significant gene expression changes in the hypothalamo-pituitary-gonadal (HPG) axis between egg production levels. Fold change and significance are presented for key HPG axis genes outside and during the preovulatory surge (RPKM> 0.2, P < 0.05). Negative fold change values represent increased expression in low egg producing hens (LEPH) and positive fold change values represent increased expression in high egg producing hens (HEPH)

From: Transcriptome analysis of the hypothalamus and pituitary of turkey hens with low and high egg production

Tissue Gene Function Fold P-Value
Outside Preovulatory Surge
Hypothalamus PRL prolactin signaling −2.65 0.0245
CYP19A1 steroid hormone biosynthesis −1.52 0.0292
CYP1A1 steroid hormone biosynthesis 1.92 0.0092
HSD11B1 steroid hormone biosynthesis 1.67 0.0448
Pituitary CGA HPG axis signaling 1.59 0.0217
AR steroid hormone signaling −1.59 0.0126
STAR steroid hormone biosynthesis −16.73 0.0000
During Preovulatory Surge
Tissue Gene Function Fold P-Value
Hypothalamus GNRH1 HPG axis signaling −2.54 0.0362
NPVF HPG axis signaling −1.78 8.39E-06
FSHR HPG axis signaling −7.03 0.0002
ESR2 steroid hormone signaling 1.35 0.0218
PRL prolactin signaling 1.87 0.0299