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Table 3 Upstream regulators. Significant upstream regulators between low egg producing hens (LEPH) and high egg producing hens (HEPH), outside and during the preovulatory surge (RPKM> 0.2, P < 0.05, |fold change| > 1.5)

From: Transcriptome analysis of the hypothalamus and pituitary of turkey hens with low and high egg production

Tissue Upstream Regulator Molecule Type Z-Score P-Value Target Genes
Outside Prevoulatory Surge
Hypothalamus cyclosporin A biologic drug 0.678 1E-06 10
MAPK8 kinase 0.889 2E-06 6
Pkc(s) group 0.119 3E-06 7
FOXF2 transcription regulator −2 5E-06 4
FOXA2 transcription regulator 1 6E-06 7
Pituitary DAP3 other 3 4E-08 7
actinonin chemical reagent −3 1E-06 7
ALKBH1 enzyme 2.449 5E-06 4
NSUN3 enzyme 2.449 5E-06 4
SIRT3 enzyme −1.952 0.0003 8
During Prevoulatory Surge
Hypothalamus LOXL2 enzyme −1.406 2E-06 3
FGF2 growth factor −0.307 3E-06 15
beta-estradiol chemical-endogenous −1.064 2E-05 39
Mek group 1.315 2E-05 9
BMP2 growth factor −1.014 3E-05 8
Pituitary ESR1 nuclear receptor 0.991 4E-06 41
beta-estradiol chemical-endogenous 1.749 2E-05 49
ESR2 nuclear receptor −0.842 0.0001 17
CDH2 other −1.103 0.0002 4
cholic acid chemical-endogenous 0.761 0.001 6