Table 3 Upstream regulators. Significant upstream regulators between low egg producing hens (LEPH) and high egg producing hens (HEPH), outside and during the preovulatory surge (RPKM> 0.2, P < 0.05, |fold change| > 1.5)
Tissue | Upstream Regulator | Molecule Type | Z-Score | P-Value | Target Genes |
|---|---|---|---|---|---|
Outside Prevoulatory Surge | |||||
Hypothalamus | cyclosporin A | biologic drug | 0.678 | 1E-06 | 10 |
MAPK8 | kinase | 0.889 | 2E-06 | 6 | |
Pkc(s) | group | 0.119 | 3E-06 | 7 | |
FOXF2 | transcription regulator | −2 | 5E-06 | 4 | |
FOXA2 | transcription regulator | 1 | 6E-06 | 7 | |
Pituitary | DAP3 | other | 3 | 4E-08 | 7 |
actinonin | chemical reagent | −3 | 1E-06 | 7 | |
ALKBH1 | enzyme | 2.449 | 5E-06 | 4 | |
NSUN3 | enzyme | 2.449 | 5E-06 | 4 | |
SIRT3 | enzyme | −1.952 | 0.0003 | 8 | |
During Prevoulatory Surge | |||||
Hypothalamus | LOXL2 | enzyme | −1.406 | 2E-06 | 3 |
FGF2 | growth factor | −0.307 | 3E-06 | 15 | |
beta-estradiol | chemical-endogenous | −1.064 | 2E-05 | 39 | |
Mek | group | 1.315 | 2E-05 | 9 | |
BMP2 | growth factor | −1.014 | 3E-05 | 8 | |
Pituitary | ESR1 | nuclear receptor | 0.991 | 4E-06 | 41 |
beta-estradiol | chemical-endogenous | 1.749 | 2E-05 | 49 | |
ESR2 | nuclear receptor | −0.842 | 0.0001 | 17 | |
CDH2 | other | −1.103 | 0.0002 | 4 | |
cholic acid | chemical-endogenous | 0.761 | 0.001 | 6 | |