Table 3 List of top 20 R. conorii genes differentially expressed during the infection of tick vector AAE2 cells, in vitro
Gene ID | Product | Gene Length (bp) | TPM | Log2 Change | Homologous to | ||||
|---|---|---|---|---|---|---|---|---|---|
AAE2 + Rc | HMEC + Rc | Product | Organism | E-value | Identity (%) | ||||
RC0446 | Hypothetical protein | 291 | 377 | 8 | 5.64 | M61 glycyl aminopeptidase family protein | R. rhipicephali | 6e-52 | 92% |
RC0511 | Hypothetical protein | 249 | 367 | 9 | 5.38 | Transcriptional regulator, AbrB family | R. massiliae | 1e-50 | 100% |
peg.0696 | Hypothetical protein | 132 | 539 | 17 | 5.02 | – | – | – | – |
peg.1306 | Hypothetical protein | 114 | 415 | 19 | 4.43 | Acetyl-CoA acetyltransferase | Thermoplasmata | 1e-05 | 48% |
RC0418 | Hypothetical protein | 672 | 119 | 7 | 4.18 | Tetratricopeptide repeat family protein | R. hoogstraalii | 2e-121 | 81% |
RC1248 | Hypothetical protein | 153 | 234 | 14 | 4.03 | HEPN domain-containing protein | R. asembonensis | 2e-07 | 92% |
peg.0362 | Hypothetical protein | 117 | 297 | 19 | 3.98 | – | – | – | – |
peg.0481 | Hypothetical protein | 198 | 338 | 22 | 3.93 | CPBP family intramembrane metalloprotease | R. gravesii | 4e-35 | 93% |
RC0253 | Hypothetical protein | 270 | 343 | 24 | 3.81 | – | – | – | – |
RC0979 | DnaA regulatory inactivator Hda (Homologous to DnaA) | 669 | 138 | 10 | 3.81 | Â | Â | Â | Â |
RC0034 | Dihydrofolate reductase (FolA) | 495 | 62 | 4 | 3.8 | Â | Â | Â | Â |
RC0570 | RND efflux system, membrane fusion protein | 297 | 282 | 22 | 3.67 | Â | Â | Â | Â |
RC1250 | Hypothetical protein | 246 | 417 | 36 | 3.54 | Palindromic element RPE1 domain-containing protein | SFG rickettsiae | 7e-51 | 100% |
RC0640 | Hypothetical protein | 420 | 304 | 26 | 3.54 | Fimbrial biogenesis outer membrane usher protein | R. gravesii | 2e-65 | 96% |
RC0957 | Hypothetical protein | 201 | 245 | 22 | 3.49 | Tetratricopeptide repeat protein | SFG rickettsiae | 1e-17 | 97% |
RC0471 | Hypothetical protein | 249 | 193 | 18 | 3.45 | Tetratricopeptide repeat protein | R. hoogstraalii | 7e-46 | 95% |
RC0513 | Hypothetical protein | 186 | 388 | 35 | 3.45 | – | – | – | – |
peg.0400 | Hypothetical protein | 144 | 332 | 31 | 3.44 | Acid phosphatase family protein | R. amblyommatis | 5e-26 | 94% |
RC1293 | Hypothetical protein | 195 | 363 | 34 | 3.43 | – | – | – | – |
peg.0013 | Hypothetical protein | 135 | 172 | 16 | 3.4 | Toxin | R. tamurae | 0.086 | 90% |