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Fig. 4 | BMC Genomics

Fig. 4

From: A comparative analysis of chromatin accessibility in cattle, pig, and mouse tissues

Fig. 4

Conservation of regulatory element accessibility in cattle, pig, and mouse. a Summary of pairwise open chromatin conservation. Circles reflect number of consensus ATAC-seq peaks in each species. Arrow width reflects proportion of consensus peaks that could be projected to the other species. Lighter section of arrows reflect proportion of regions that could be mapped which demonstrated conserved accessibility in at least one tissue in both species. b Of regions that could be projected to all three species, number of regions with conserved accessibility in all three species and in ungulates laid over a phylogenetic tree reflective of evolutionary distance in millions of years (MYA). c Genomic distribution of regions with conserved accessibility in all three species, relative to the mouse gene annotation. Brief summary of enriched gene ontology (GO) terms for genes marked by conserved open chromatin at their TSS in every tissue. d Consensus peaks, consensus peaks with conserved sequence (that could be mapped to all three species), and consensus peaks with conserved sequence and conserved accessibility in all three species at the MEF2A locus. Tracks show normalized ATAC-seq signal. Conserved promoter open chromatin highlighted in green. Conserved distal (putative enhancer) open chromatin highlighted in yellow

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