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Table 5 Substitutions identified as “Deleterious” and “Possibly damaging/Probably damaging” both by Provean and PolyPhen2, respectively

From: Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

Gene AA position Substitution ABS SAAS
DRB1 15 G - > V NO NO
DRB1 42 Y - > V NO NO
DRB1 53 A - > P NO NO
DRB1 55 Y - > K YES NO
DRB1 72 T - > K NO NO
DRB2 23 D - > F NO NO
DRB2 25 Y - > D YES NO
DRB2 25 Y - > L YES NO
DRB2 51 P - > T YES YES
DRB3 15 G - > V NO NO
DRB3 56 W - > L NO NO
DRB3 73 Y - > V YES NO
DQB1 24 R - > T NO NO
DQB1 43 R - > L NO NO
DQB1 60 K - > D NO NO
DQB2 24 R - > S NO NO
DQB2 25 Y - > I YES YES
DQB2 67 R - > W YES NO
DQB2-like 49 G - > A YES NO
DQB2-like 51 P - > W YES YES
DQB2-like 51 P - > S YES YES
DQB2-like 51 P - > L YES YES
DQB3 10 C - > R NO NO
DQB3 53 A - > P NO NO