Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

Table 5 Substitutions identified as “Deleterious” and “Possibly damaging/Probably damaging” both by Provean and PolyPhen2, respectively

Gene	AA position	Substitution	ABS	SAAS
DRB1	15	G - > V	NO	NO
DRB1	42	Y - > V	NO	NO
DRB1	53	A - > P	NO	NO
DRB1	55	Y - > K	YES	NO
DRB1	72	T - > K	NO	NO
DRB2	23	D - > F	NO	NO
DRB2	25	Y - > D	YES	NO
DRB2	25	Y - > L	YES	NO
DRB2	51	P - > T	YES	YES
DRB3	15	G - > V	NO	NO
DRB3	56	W - > L	NO	NO
DRB3	73	Y - > V	YES	NO
DQB1	24	R - > T	NO	NO
DQB1	43	R - > L	NO	NO
DQB1	60	K - > D	NO	NO
DQB2	24	R - > S	NO	NO
DQB2	25	Y - > I	YES	YES
DQB2	67	R - > W	YES	NO
DQB2-like	49	G - > A	YES	NO
DQB2-like	51	P - > W	YES	YES
DQB2-like	51	P - > S	YES	YES
DQB2-like	51	P - > L	YES	YES
DQB3	10	C - > R	NO	NO
DQB3	53	A - > P	NO	NO

ISSN: 1471-2164