Fig. 6

Detailed functional profiling of the DEGs (P < 0.05, FC > 2 or < 0.5) between the female IUGR and female NBW piglets. a Classification of the GO terms based on the functional annotation of BP enriched in the female IUGR piglets on Day 1. The ordinate represents the GO item, the abscissa represents the number of enriched DEGs corresponding to each term and the color column represents the enrichment score (defined as -Log10 P-value). b The GOCircle plot of the female IUGR piglets on Day 1. The outer circle shows a scatter plot for each term of the logFC of the assigned genes. Red circles display the up-regulated genes and the blue circles indicate the down-regulated genes by default. c The GOChord plot of female IUGR piglets on Day 1, and the DEGs that were assigned to at least three process terms were selected. d The protein-protein interaction network of the DEGs in female IUGR piglets on Day 1. The red nodes indicate the upregulated genes and the green nodes indicate the downregulated genes in the IUGR piglets. Fold-changes (FC) in gene expression are expressed as log2 (FC) values. e The tables show the major functions of the DEGs that were selected in the female IUGR piglets on Day 1. f GO enrichment analysis of the DEGs of BP enriched in female IUGR piglets on Day 7. g GO enrichment analysis of the DEGs of BP enriched in female IUGR piglets on Day 28