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Fig. 7 | BMC Genomics

Fig. 7

From: Clustering analysis of large-scale phenotypic data in the model filamentous fungus Neurospora crassa

Fig. 7

Cluster genes dependent on the three MAPKs: MAK-1, MAK-2 and OS-2. Data for identification of genes with down-regulated expression in a N. crassa Δmak-1 mutant were obtained from Ref. [44]. For mining cluster genes encoding transcriptional or phosphorylation targets of MAK-2 in N. crassa, targets were compiled from four datasets, including microarray analysis of genes down-regulated in a Δmak-2 mutant [41] or down-regulated in a strain expressing the mak-2Q100G strain in the presence of inhibitor [45], and MAK-2 phosphorylation targets identified during phosphoproteomics studies with the mak-2Q100G strain with inhibitor [46, 47]. Cluster genes encoding N. crassa orthologs of transcriptional targets of the p38 MAPK (os-2) in Cryptococcus neoformans and Aspergillus fumigatus were obtained using data from Ref. [48, 49]. N. crassa orthologs in the combined dataset were retrieved using the “Transform by Orthology” tool at FungiDB. The numbers above the blue, orange and green bars indicate the percent of genes in each cluster that are either regulated by MAK-1, MAK-2 and the p38 MAPK (OS-2), respectively. Raw data are available in Additional file 7

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