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Fig. 1 | BMC Genomics

Fig. 1

From: Functional module detection through integration of single-cell RNA sequencing data with protein–protein interaction networks

Fig. 1

Our method consists of the following steps. (1) clustering of scRNA-seq data (e.g., with SEURAT [9]). For each cluster, we (2) compute p-values of differential expression and use them to (3) estimate node scores by using an approach presented in [33]. (4) We combine these node scores with a PPIN to construct node-weighted PPINs for each cluster. (5) We compute functional modules as maximum-weight connected subgraphs

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BMC Genomics

ISSN: 1471-2164

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