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Table 1 For each of the seven clusters we give the three most enriched GO terms and the multiple-testing-corrected p-values that we received from Fisher’s exact tests. For these GO terms, we also give the fold-enrichment as the fraction of genes in the module with this annotation over the total number of genes with this annotation in the whole data set

From: Functional module detection through integration of single-cell RNA sequencing data with protein–protein interaction networks

Cluster

Module sizeM

Top enriched GO terms (fold-enrichment)

log10(p-value)

H1

51

translational initiation (15/158)

−6

  

nuclear-transcribed mRNA catabolic process (14/101)

−6

  

SRP-dependent cotranslational protein targeting to membrane (14/90)

−5

H2

52

response to stress (32/491)

−2

  

defense response (19/200)

−2

  

cell maturation (6/18)

−2

H3

27

SRP-dependent cotranslational protein targeting to membrane (24/78)

−26

  

nuclear-transcribed mRNA catabolic process (24/86)

−26

  

translational initiation (24/105)

−24

H4

3

none

 

H5

30

extracellular structure organization (9/25)

−3

  

exocytosis (12/203)

−2

  

alcohol metabolic process (9/69)

−3

H6

1

none

 

H7

253

SRP-dependent cotranslational protein targeting to membrane (78/88)

−26

  

nuclear-transcribed mRNA catabolic process (78/90)

−26

  

cotranslational protein targeting to membrane (78/91)

−26