Fig. 2
From: Analysing the meta-interaction between pathways by gene set topological impact analysis
Demonstration of the similarities and upstream/downstream relationships between oncogenic pathways and DNA repair pathways. a. The heatmap of the Jaccard Index matrix of oncogenic pathways and DNA repair pathways. Fonts in blue represent oncogenic pathways, fonts in pink represent DNA repair pathways. b. The heatmap of the GESTIA scores between oncogenic pathways and DNA repair pathways. The color set and orders of the rows and columns are the same as in a. c. The undirected weighted network constructed using the Jaccard Index matrix as an adjacency matrix. The weights of the edges are proportional of the Jaccard Index scores in the matrix. Blue represent oncogenic pathways, pink represent DNA repair pathways. d. The directed weighted network constructed using the GESTIA matrix as an adjacency matrix. Negative values were filtered out because of the symmetry of the matrix. The color set are the same as in c