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Fig. 5 | BMC Genomics

Fig. 5

From: Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection

Fig. 5

Biomarkers of fetal preservation in the placenta. Relative expression of 7 differentially expressed genes (DEG) found in the placenta in the MEC + F (PLCO-MEC + LVL-MEC + HVL-MEC vs UNINF + PLCO-VIA + LVL-VIA + HVL-VIA) contrast group; A) NFKB2, NFKBIA, FASLG, B2M, and B) DNTT, GZMB, and CCL4 [Note difference in scale for A) versus B).]. The log2FC for each group was calculated in contrasted to control (CTRL); uninfected (UNINF), placenta only with viable (PLCO-VIA), PLCO with meconium staining (PLCO-MEC), low viral load with VIA (LVL-VIA), LVL-MEC, high viral load VIA (HVL-VIA) and HVL-MEC. V + F calculated as (LVL-VIA, LVL-MEC, HVL-VIA, and HVL-MEC) contrasted to V - F (UNINF, PLCO-VIA, and PLCO-MEC). MEC + F calculated as (PLCO-MEC, LVL-MEC, and HVL-MEC) contrasted to MEC - F (UNINF, PLCO-VIA, LVL-VIA, and HVL-VIA). Pink is UNINF, purple is PLCO-VIA, dark blue is PLCO-MEC, red is LVL-VIA, yellow is LVL-MEC, blue is HVL-VIA, green is HVL-MEC, orange is V + F, and grey is MEC + F. *indicates significance P < 0.05 calculated in Limma

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