Fig. 5From: Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infectionBiomarkers of fetal preservation in the placenta. Relative expression of 7 differentially expressed genes (DEG) found in the placenta in the MEC + F (PLCO-MEC + LVL-MEC + HVL-MEC vs UNINF + PLCO-VIA + LVL-VIA + HVL-VIA) contrast group; A) NFKB2, NFKBIA, FASLG, B2M, and B) DNTT, GZMB, and CCL4 [Note difference in scale for A) versus B).]. The log2FC for each group was calculated in contrasted to control (CTRL); uninfected (UNINF), placenta only with viable (PLCO-VIA), PLCO with meconium staining (PLCO-MEC), low viral load with VIA (LVL-VIA), LVL-MEC, high viral load VIA (HVL-VIA) and HVL-MEC. V + F calculated as (LVL-VIA, LVL-MEC, HVL-VIA, and HVL-MEC) contrasted to V - F (UNINF, PLCO-VIA, and PLCO-MEC). MEC + F calculated as (PLCO-MEC, LVL-MEC, and HVL-MEC) contrasted to MEC - F (UNINF, PLCO-VIA, LVL-VIA, and HVL-VIA). Pink is UNINF, purple is PLCO-VIA, dark blue is PLCO-MEC, red is LVL-VIA, yellow is LVL-MEC, blue is HVL-VIA, green is HVL-MEC, orange is V + F, and grey is MEC + F. *indicates significance P < 0.05 calculated in LimmaBack to article page