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Fig. 7 | BMC Genomics

Fig. 7

From: Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection

Fig. 7

Pathway enrichment of differentially expressed genes in the fetal thymus. A) low viral load with viable (LVL-VIA) contrasted to control (CTRL) fetuses. B) LVL with meconium staining (LVL-MEC) contrasted to CTRL fetuses. C) high viral load with viable (HVL-VIA) contrasted to CTRL fetuses. D) HVL with meconium staining (HVL-MEC) contrasted to CTRL fetuses. E) Virus positive fetus aka V + F (LVL-VIA, LVL-MEC, HVL-VIA, and HVL-MEC) contrasted to virus negative fetus V - F [UNINF, placenta only with VIA (PLCO-VIA), and PLCO-MEC]. F) Meconium stained fetus aka MEC + F (PLCO-MEC, LVL-MEC, and HVL-MEC) contrasted to viable fetus aka MEC - F (UNINF, PLCO-VIA, LVL-VIA, and HVL-VIA). The percent enrichment was calculated as the [(number of DEG assigned to a given pathway by IPA + the number of DEG manually assigned)/(total number of genes assayed on the NanoString in the given pathway)*100]. The pathway analysis plotted with pathway name on the y axis, enrichment (%) on the x, bubble size as the total number of DEG in each pathway, and the color as the IPA predicted activation Z score with blue deactivated and red activated

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BMC Genomics

ISSN: 1471-2164

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