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Table 5 Analysis of differentially expressed genes (|fold change| > 1.5 at a false discovery rate < 0.05) in association with matrix protein, calcium transport, immune response and defense mechanism

From: Uterine transcriptome analysis reveals mRNA expression changes associated with the ultrastructure differences of eggshell in young and aged laying hens

Potential function

Gene (Fold change)

Annotation

Matrix protein

VCAN (1.55)

Versican, chondroitin sulfate proteoglycan, calcium ion binding

 

CDH6 (1.71)

Cadherin 6, calcium binding, in association with the physiological control of bone remodeling

 

LOC107056462 (1.61)

Alpha-actinin-1-like, calcium binding

 

PLCL1 (1.61)

Phospholipase C like 1, calcium binding

 

OVAL (1.52)

Ovalbumin, regulate shell structure and present in eggshell

 

GPC3 (0.64)

Glypican 3, regulate the activity of bone morphogenetic proteins and promote bone formation

 

DMP1 (0.66)

Dental matrix protein-1, in association with tissue mineralization

Calcium transport

CACNA1C (1.79)

Voltage-dependent L-type calcium channel subunit alpha-1C, ion transport protein, voltage-gated calcium channel activity

 

CACNA1D (1.68)

Voltage-dependent L-type calcium channel subunit alpha-1D, ion transport protein, voltage-gated calcium channel activity

 

NMUR2 (1.52)

Thyrotropin-releasing hormone receptor, calcium ion transport

Immune response

BF2 (0.66)

MHC class I antigen BF2, antigen processing and presentation

 

MHCIA5 (0.58)

Major histocompatibility complex, class I, A5, antigen processing and presentation

 

MHCIA6 (0.62)

Major histocompatibility complex, class I, A6, antigen processing and presentation

 

YF5 (0.64)

MHC class I antigen YF5, antigen processing and presentation

 

LOC101748499 (1.64)

Class II histocompatibility antigen, B-L beta chain-like, immune response

 

IL7 (1.63)

Interleukin 7, a cytokine important for B and T cell development

 

C7 (1.61)

Complement C7, as part of the terminal complement pathway of the innate immune system

 

KCTD7 (1.71)

Potassium channel tetramerization domain containing 7, negative regulation of inflammation

Defense mechanism

ABCA13 (1.65)

ATP-binding cassette, sub-family A, membrane 13, defense mechanism

 

LOC107056420 (1.50)

Intestinal mucin-like protein, defense mechanism