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Fig. 2 | BMC Genomics

Fig. 2

From: Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis

Fig. 2

CRISPR-Cas locus reconstitution for one archetypal isolate of each lineage. Note that the direction of CRISPR-Cas locus is antisense in H37Rv i.e. the displayed orientation is reverse as compared to H37Rv genome. Full arrows indicate genes. Red empty arrows indicate IS6110 sequences. Diamonds indicate spacers. Boxes indicated Direct Repeats (DR). Width of spacers and DR have been artificially expanded for clarity. Shorter boxes indicate truncated DR. The pink empty box highlights a duplicated spacer at an unexpected position (not in tandem). Color codes for genes (arrows): light blue: cas genes involved in immunity (interference); dark blue: cas genes involved in adaptation; grey: IS6110 genes (transposase and hypothetical protein); white: other neighbouring gene of unknown function. The color of spacers was attributed randomly to facilitate visual exploration but spacers of the same color have no link except if they carry the same number. When a DR0 borders a deletion, we chose to represent it in most of the cases at the beginning of the deletion, although choosing the end of the deletion would have been equally relevant. Mutated DR are indicated in black. Mutated versions of spacers are highlighted by a star and by a yellow font

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