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Fig. 4 | BMC Genomics

Fig. 4

From: Cell-specific characterization of the placental methylome

Fig. 4

DNA methylation at partially methylated domains (PMDs), and imprinted differentially methylated regions (DMRs). a The percentage (y-axis) of CpGs in placental PMDs, falling into specific methylation intervals (0ā€“20%, 20ā€“40%, 40ā€“60%, etc.) is shown for each cell type and trimester. b DNAm across specific regions on chromosome 21 (B) and 4 (c). PMDs are highlighted with a grey background. d Density plots (y-axis) of imprinted DMRs in term samples, divided into those that are imprinted in multiple tissues, (i.e. non-placental-specific; 1085 CpGs total; top) and placental-specific (981 CpGs total; bottom). The percentage of CpGs falling within 25%ā€“75% is shown above each plot. e Cell-specific DNAm at the C19MC placental-specific imprinted DMR. This placental-specific imprint overlies a CpG island upstream of the miRNA cluster. f DNAm at placental-specific imprinted region for DCAF10

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