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Fig. 5 | BMC Genomics

Fig. 5

From: jouvence, a new human snoRNA involved in the control of cell proliferation

Fig. 5

Hundreds of genes are deregulated in HCT116 cells overexpressing jouvence. a Transcriptomic analysis (RNA-Seq) performed on total-RNA (enriched for poly-A) from the overexpressing jouvence HCT116 cells compared to the empty vector cells, reveals that 5918 genes are deregulated, in which 2974 are upregulated, while 2944 are downregulated (see Suppl. Table S1 and Suppl. Table S2 for the complete list of genes). b Statistic of enrichment pathway of the deregulated genes according to the KEGG analysis (see Suppl. Table S3) for the full list of KEGG analysis. Rich factor is the ratio of numbers of differentially expressed genes annotated in this pathway term to the numbers of all genes annotated in this pathway term. Greater rich factor means greater intensiveness. Q-value is corrected P-value ranging from 0  1, with a lower value means greater intensiveness. Top 20 pathway terms enriched are displayed in the figure. In brief, the metabolic pathways are the main deregulated pathways in term of number of genes, while the ribosome is the main deregulated pathway in term of strength (Rich factor)

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