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Table 2 Functional classes for genes with highly variable core promoters

From: Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition

Functional pathways

Number of genes

Signalling

 Cytokine Signaling in Immune system

115

 G alpha (s) signalling events

225

 GPCR downstream signalling

301

 Olfactory Signaling Pathway

201

 Signal Transduction

492

 Signaling by G protein–coupled receptors (GPCR)

307

Metablism

 Metabolism

395

 Metabolism of proteins

397

 Metabolism of RNA

172

Immune

 Adaptive Immune System

110

 Immune System

328

 Innate Immune System

189

Gene expression

 Gene expression (Transcription)

231

 Generic Transcription Pathway

177

 RNA Polymerase II Transcription

203

Others

 Cell Cycle

116

 Developmental Biology

241

 Disease

150

 Post-translational protein modification

232

 Transport of small molecules

113

Total*

4695*

  1. *Including genes involved in multiple functional pathways