Fig. 2

Genome-wide sequence depth of CpG locations. WGBS was used to evaluate CpG methylation profiles within the genome of each edited and control animal. The distribution of the number of CpG calls observed is shown for HDR1 Animal (a) with 10,835,815 CpG locations with ≥5 calls, HDR2 Animal (b) with 10,109,462 CpG locations with ≥5 calls, NHEJ1 Animal (c) with 6,382,801 CpG locations with ≥5 calls, Control 1 Animal (d) with 11,948,365 CpG locations with ≥5 calls, and Control 2 Animal (e) with 8,754,364 CpG locations with ≥5 calls. The numbers of CpG locations are reported in millions (M)