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Table 4 Case 1 p-value rankings for HDR2 Animal compared to Control 1 Animal

From: Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

     

Degree of Experimental Methylation Level Higher Than Control

Chromosome

CpG Island Start Location

CpG Island End Location

p-value

CpG Count

1–20% Proportion

1–20%

21–40%

41–60%

61–80%

81–100%

6

113,076,186

113,077,861

5.384E-23

135

0.229

19

45

19

0

0

16

4,846,725

4,846,950

2.937E-10

12

0.000

0

1

10

1

0

1

126,092,971

126,093,200

3.224E-10

16

0.313

5

11

0

0

0

12

84,038,314

84,038,998

3.593E-10

37

0.406

13

14

5

0

0

6

3,200,773

3,201,615

8.468E-10

35

0.355

11

20

0

0

0

7

31,208,206

31,208,620

1.111E-08

24

0.455

10

11

1

0

0

3

101,982,373

101,982,595

4.617E-08

27

0.480

12

9

4

0

0

10

126,861,656

126,861,911

1.620E-07

15

0.200

3

7

5

0

0

2

34,639,014

34,639,339

2.409E-07

22

0.400

8

10

2

0

0

  1. The p-value represents the upper-tail p-value for the hypothesis test of higher methylation in the experimental mouse than the control mouse. The CG count includes the total number of CGs in the CpG island. The proportion and category counts only refer to the number of CGs where the experimental CG methylation level is higher than the control CG methylation level