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Table 4 Case 1 p-value rankings for HDR2 Animal compared to Control 1 Animal

From: Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

      Degree of Experimental Methylation Level Higher Than Control
Chromosome CpG Island Start Location CpG Island End Location p-value CpG Count 1–20% Proportion 1–20% 21–40% 41–60% 61–80% 81–100%
6 113,076,186 113,077,861 5.384E-23 135 0.229 19 45 19 0 0
16 4,846,725 4,846,950 2.937E-10 12 0.000 0 1 10 1 0
1 126,092,971 126,093,200 3.224E-10 16 0.313 5 11 0 0 0
12 84,038,314 84,038,998 3.593E-10 37 0.406 13 14 5 0 0
6 3,200,773 3,201,615 8.468E-10 35 0.355 11 20 0 0 0
7 31,208,206 31,208,620 1.111E-08 24 0.455 10 11 1 0 0
3 101,982,373 101,982,595 4.617E-08 27 0.480 12 9 4 0 0
10 126,861,656 126,861,911 1.620E-07 15 0.200 3 7 5 0 0
2 34,639,014 34,639,339 2.409E-07 22 0.400 8 10 2 0 0
  1. The p-value represents the upper-tail p-value for the hypothesis test of higher methylation in the experimental mouse than the control mouse. The CG count includes the total number of CGs in the CpG island. The proportion and category counts only refer to the number of CGs where the experimental CG methylation level is higher than the control CG methylation level