Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

BMC Genomics

Table 5 Case 1 p-value rankings for NHEJ1 Animal compared to Control 1 Animal

					Degree of Experimental Methylation Level Higher Than Control
Chromosome	CpG Island Start Location	CpG Island End Location	p-value	CpG Count	1–20% Proportion	1–20%	21–40%	41–60%	61–80%	81–100%
2	153,071,685	153,072,285	1.222E-08	53	0.455	20	18	6	0	0
5	133,842,301	133,842,658	3.997E-07	9	0.000	0	6	3	0	0
7	96,797,289	96,797,521	6.555E-07	10	0.300	3	7	0	0	0
15	38,118,394	38,118,655	7.027E-07	9	0.000	0	5	4	0	0
3	71,974,851	71,975,406	8.074E-07	6	0.000	0	6	0	0	0

The p-value represents the upper-tail p-value for the hypothesis test of higher methylation in the experimental mouse than the control mouse. The CG count includes the total number of CGs in the CpG island. The proportion and category counts only refer to the number of CGs where the experimental CG methylation level is higher than the control CG methylation level

ISSN: 1471-2164