Fig. 3

Network visualization of the effect of vitrification/warming on cat ovarian cortex. a Enrichment map displaying enriched gene-sets based on differentially expressed genes between vitrified (V) and fresh (F) tissue. Red node color represents enrichment in vitrified ovarian cortex (i.e., up-regulation after vitrification), whereas blue represents enrichment in fresh tissue (i.e., down-regulation after vitrification). Borders are colored according to the enrichment p-value (EASE score). Clusters of functionally related gene-sets were identified using DAVID tool, manually circled and assigned a label. Additional file 4 contains the web session of the network for interactive view. b STRING network for 89 proteins retrieved from the list of differentially expressed genes in comparison pair V vs. F. Full gene list of the pair V vs. F resulted in 38 functional associations between 18 of the proteins; proteins with less than 2 associations to other proteins in the network were removed from visualization. Each cluster was analyzed for functional enrichment within STRING app. Nodes are colored according to the gene abundance (fold change) in comparison pair V vs. F; borders are colored according to the adjusted p-value (q-value) of the differentially expressed gene. The confidence cutoff was set to 0.4, the confidence score of each interaction is mapped to the edge thickness. Additional file 5 contains the web session of the network for interactive view