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Table 2 Odds Ratio for the Top Suggestive SNPs on CFAs 11, 16, and 29

From: Genetic characterization of Addison’s disease in Bearded Collies

Genotype Controls
(N = 85)
AD cases
(N = 55)
OR (95% CI)* p-value
CFA11 SNP (BICF2G630307993–71,446,591; CanFam3.1 reference allele A)#
G G 1 11 21.0 (2.63–167.99) 0.00015
G A 29 23 1.4 (0.69–2.79) 0.37576
A A 55 21 0.3 (0.17–0.68) 0.00303
G G 1 11
vs 28.8 (3.50–237.15) 0.00004
A A 55 21
G A 29 23
vs 2.1 (0.99–4.37) 0.06010
A A 55 21
CFA16 SNP (BICF2G630109748–27,126,780; CanFam3.1 reference allele C)
G G 40 43 4.0 (1.87–8.70) 0.00038
C G 35 12 0.4 (0.18–0.86) 0.02728
C C 10 0 NA§ 0.01403
G G 40 43
vs NA 0.00151
C C 10 0
C G 35 12
vs NA 0.09974
C C 10 0
CFA29 SNP (BICF2P977298–30,615,809; CanFam3.1 reference allele A)
C C 16 27 4.2 (1.95–8.88) 0.00019
C A 47 20 0.5 (0.23–0.93) 0.03760
A A 22 8 0.5 (0.20–1.19) 0.14087
C C 16 27
vs 4.6 (1.68–12.85) 0.00397
A A 22 8
C A 47 20
vs 1.2 (0.45–3.07) 0.81259
A A 22 8
  1. Odds ratio (OR) for the top suggestive single nucleotide polymorphisms (SNPs) on chromosomes 11, 16, and 29 in 140 Bearded Collies (55 Addison’s disease (AD) cases, 85 healthy controls). Bolded values were statistically significant at p < 0.05.
  2. §NA not enough data points collected for OR calculation,*CI Confidence interval, #SNP locations are based on the CanFam3.1 reference genome