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Table 3 Probability of Disease Based on Number of Risk Genotypes

From: Genetic characterization of Addison’s disease in Bearded Collies

Number of SNPs in model CFA18 CFA11 CFA16 CFA29 Controls (N = 85) AD
(N = 55)
Probability of disease 95% CI*
Single SNP A A 7 9 0.540 0.328–0.747
Single SNP A G 19 30 0.613 0.479–0.744
2-SNP A A G G 1 1 0.877 0.637–0.988
2-SNP A G G G 0 7 0.925 0.770–0.991
2-SNP A A G G 4 8 0.641 0.407–0.834
2-SNP A G G G 11 22 0.697 0.552–0.824
2-SNP A A C C 1 5 0.757 0.524–0.915
2-SNP A G C C 2 14 0.822 0.677–0.924
3-SNP A A G G G G 1 1 0.885 0.653–0.988
3-SNP A G G G G G 0 7 0.926 0.779–0.991
3-SNP A A G G C C 0 1 0.950 0.803–0.996
3-SNP A G G G C C 0 4 0.973 0.902–0.998
3-SNP A A G G C C 0 5 0.833 0.619–0.952
3-SNP A G G G C C 0 11 0.872 0.750–0.953
4-SNP A A G G G G C C 0 1 0.956 0.821–0.997
4-SNP A G G G G G C C 0 4 0.974 0.901–0.998
  1. Probability of disease associated with carrying one, two or three risk genotypes at the suggestive single nucleotide polymorphisms (SNPs) on chromosomes 11, 16 and/or 29 in addition to a CFA18 risk genotypes for Addison’s disease (AD) in 140 Bearded Collies (55 AD cases, 85 healthy controls). Comparisons provided are for genotypes associated with significant risk as detailed in Table 2. Bolded values indicate significant increase in the probability of disease associated with the additive effect of risk genotypes across 2 SNPs, 3 SNPs and all 4 SNPs of interest.
  2. * CI Confidence interval