Genetic characterization of Addison’s disease in Bearded Collies

BMC Genomics

Table 4 Probability of Disease for Dogs Carrying only Non-risk Genotypes

SNP Genotypes				Number of Dogs with Genotype Combination in Dataset		Probability of Disease
CFA18	CFA11	CFA16	CFA29	Controls (N = 85)	AD cases (N = 55)	Probability	95% CI*
G G	A A	C C	A A	0	0	0.024	0.002–0.087 ^a
G G	A A	C C	C A	3	0	0.021	0.002–0.079
G G	A A	C G	A A	3	0	0.067	0.016–0.170
G G	A A	C G	C A	10	0	0.056	0.014–0.131
G G	G A	C C	A A	0	0	0.061	0.006–0.209 ^a
G G	G A	C C	C A	2	0	0.052	0.005–0.190
G G	G A	C G	A A	3	0	0.157	0.044–0.355
G G	G A	C G	C A	7	1	0.134	0.041–0.558

The table shows the probability of Addison's disease (AD) for dogs carrying only non-risk genotypes at all four single nucleotide polymorphisms (SNPs) of interest
*CI Confidence interval
^aalthough none of the dogs in the dataset carried these genotypic combinations, logistic regression model allowed for the estimation of the probability of disease given the known genotypes and phenotypes.

ISSN: 1471-2164