Fig. 6
Enriched Ingenuity Pathway Analysis canonical pathways (P < 0.05, FDR < 0.1). Enriched pathways among the closest downstream genes to the ROCs predicted to be differentially accessible by both DeSeq2 and EdgeR, which were also predicted to be differentially expressed in the RNA-Seq analysis (P < 0.05, FDR < 0.1, fold change > 2). The pathways are shown on the x-axis and the –Log10 Benjamini-Hochberg adjusted p-values are displayed on the y-axis. The threshold is set to 1 which equals a Benjamini-Hochberg adjusted p-value of 0.1. Bars representing pathways with a positive, zero or negative z-score are coloured with orange, white or blue, respectively. Bars representing pathways where no activity could be determined from the z-score are coloured in grey