Fig. 2

Homology model of P1 putative kinase domain. The kinase domain of Receptor-interacting serine/threonine-protein kinase 2 (RIPK2, 6fu5.1.B in the rcsb protein database) is the template used for the homology modelling of P1. The X-RAY diffraction 3.26 Å was used to determine the experimental structure of 6fu5.1 [60]. The blue color show regions of the model where P1 was well-modeled and orange regions where P1 was poorly modeled. The well-modeled regions (blue) are regions where P1 is likely to be similar to the experimental 3D structure of the template. The homology model pertains to the putative kinase domain of P1 and starts from P1 residue N°3 (GLN, Glutamine) and ends with the residue N° 284 (LYS, Lysine)