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Table 2 Significant SNPs and candidate genes for average daily gain and lean meat percentage in the single-population GWAS

From: A meta-analysis of genome-wide association studies for average daily gain and lean meat percentage in two Duroc pig populations

Trait1

(population)

SNP2

SSC3

Location4

(bp)

EPV5

(%)

P-value6

Distance7

(bp)

Candidate gene

ADG (AD)

H3GA0003149

1

162,192,627

0.91

6.07 × 10− 7

within

ALPK2

WU_10.2_1_179575045

1

161,987,727

0.92

7.45 × 10− 7

within

ENSSSCG00000004911

ALGA0006684

1

161,853,405

0.93

4.49 × 10− 6

within

ENSSSCG00000004911

MARC0013872

1

161,824,864

0.79

1.12 × 10− 5

within

ENSSSCG00000004911

ASGA0004988

1

159,881,634

0.83

1.15 × 10− 5

within

CDH20

ALGA0006623

1

160,347,188

0.76

2.31 × 10− 5

within

ENSSSCG00000048538

Affx-114,594,216

6

168,268,278

0.65

3.28 × 10−7

13,851

ENSSSCG00000039458

DIAS0000782

8

30,256,709

0.45

2.51 × 10−5

32,698

TMEM156

WU_10.2_11_86301815

11

78,432,491

0.66

2.09 × 10− 5

within

MCF2L

WU_10.2_14_8843751

14

7,988,327

0.24

1.97 × 10−5

−26,761

STC1

LMP (AD)

WU_10.2_1_179575045

1

161,987,727

0.47

3.22 × 10− 6

within

ENSSSCG00000004911

H3GA0003149

1

162,192,627

0.47

3.24 × 10− 6

within

ALPK2

MARC0013872

1

161,824,864

0.65

6.00 × 10− 6

within

ENSSSCG00000004911

ALGA0006684

1

161,853,405

0.60

1.25 × 10−5

within

ENSSSCG00000004911

ALGA0006623

1

160,347,188

0.59

1.38 × 10−5

within

ENSSSCG00000048538

ALGA0123800

1

254,207,127

1.48

1.99 × 10−5

within

RGS3

ASGA0004988

1

159,881,634

0.51

2.13 × 10−5

within

CDH20

WU_10.2_2_82907810

2

81,306,158

1.44

5.91 × 10−6

− 3295

SNCB

10,006,986

2

76,416,246

1.10

7.03 × 10− 6

within

AMH

ASGA0096606

6

48,241,180

1.01

5.17 × 10−10

−31,313

LGALS13

ASGA0091829

6

48,289,460

0.71

2.07 × 10−7

16,384

DYRK1B

WU_10.2_6_41924003

6

46,461,817

0.87

7.05 × 10−6

within

ZNF570

Affx-114,594,216

6

168,268,278

0.41

1.87 × 10−5

13,851

ENSSSCG00000039458

ALGA0105911

12

27,109,190

1.23

6.92 × 10−6

− 8767

WFIKKN2

WU_10.2_15_156432561

15

57,333,035

0.58

3.08 × 10−6

within

ARHGEF4

ADG (CD)

ASGA0004970

1

158,589,475

0.94

1.66 × 10−5

53,338

PHLPP1

LMP (CD)

ASGA0002401

1

38,161,769

2.75

1.87 × 10−6

within

NKAIN2

MARC0034815

1

38,185,044

2.75

1.87 × 10−6

within

NKAIN2

MARC0026342

1

38,189,919

2.75

1.87 × 10−6

within

NKAIN2

H3GA0001475

1

37,366,714

2.18

2.78 × 10−6

− 135,329

HEY2

DRGA0000591

1

37,381,311

2.12

4.48 × 10−6

−149,926

HEY2

MARC0114211

1

37,401,594

2.12

4.48 × 10−6

− 170,209

HEY2

DRGA0000604

1

38,067,414

2.09

6.49 × 10−6

within

NKAIN2

ASGA0101182

1

37,746,276

2.06

8.68 × 10−6

within

TPD52L1

MARC0013872

1

161,824,864

1.76

1.02 × 10−5

within

ENSSSCG00000004911

ASGA0004988

1

159,881,634

1.74

1.33 × 10− 5

within

CDH20

ALGA0006602

1

159,538,854

1.72

1.53 × 10−5

within

RNF152

H3GA0003104

1

159,619,891

1.72

1.53 × 10−5

−17,910

RNF152

H3GA0001466

1

37,024,102

1.18

1.76 × 10−5

−172

HINT3

ALGA0006623

1

160,347,188

1.72

1.77 × 10−5

within

ENSSSCG00000048538

WU_10.2_1_178188861

1

160,447,734

1.72

1.77 × 10−5

98,849

ENSSSCG00000048538

INRA0004898

1

158,811,662

1.64

2.46 × 10−5

within

PHLPP1

MARC0075909

1

159,238,083

1.66

2.51 × 10−5

within

RELCH

ASGA0020293

4

74,693,408

1.38

9.37 × 10−6

within

FAM110B

H3GA0013036

4

74,714,319

1.38

9.37 × 10− 6

within

FAM110B

MARC0093868

4

74,774,997

1.38

9.66 × 10−6

−29,012

FAM110B

  1. 1ADG Average daily gain, LMP Lean meat percentage, AD American Duroc pig population, CD Canadian Duroc pig population. 2SNP ID in boldface represents the SNP had pleiotropic effects on ADG and LMP. 3SSC Sus scrofa chromosome. 4SNP positions in Ensembl. 5EPV Explained phenotypic variance. 6P-value in boldface: genome-wide significant; P-value not in boldface: suggestive significant. 7+/−: the SNP located upstream/downstream of the nearest gene