Fig. 5

Inflammation as potential therapeutic targets in ischemic stroke treatment for female animals. Venn diagram visualizing differentially expressed genes in the occluded middle cerebral artery compared with control MCAs that overlaps between the overrepresented Reactome pathway, cytokine signaling in immune system (Fig. 3), and overrepresented GO biological process terms, inflammatory response, cellular response to interleukin-1 and cellular response to tumor necrosis factor (Table 1). Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (Nfkb1) and nuclear factor kappaB subunit p65 (Rela) were annotated to each of them. Focusing solely on the GO biological process terms, this was also the case for intercellular adhesion molecule 1 (Icam1), zinc finger CCCH type containing 12A (Zc3h12a), chitinase-3-like protein 1 (Chi3l1) and several chemokines (e.g. C-C motif chemokine 2 (Ccl2)), in addition to Nfkb1 and Rela