Fig. 9

Overlapping differentially expressed genes between three experimental tMCAO stroke groups (current and previous study). Venn diagram illustrating the number of overlapping differentially expressed genes between the following experimental stroke groups (tMCAO [transient middle cerebral artery occlusion] stroke model): (i) Occluded versus non-occluded middle cerebral arteries (MCAs) from Wistar-Kyoto (WKY) male rats (results from Grell et al. [20]), (ii) Occluded MCAs vs control MCAs from Wistar female rats, and (iii) Non-occluded MCAs vs control MCAs from Wistar female rats. Here, we identified an overlap of 149 genes between group (ii) and (iii) in contrast to 147 genes observed in Fig. 1 where both upregulation and downregulation of the genes were considered. The reason for the discrepancy is due to (1) Tetratricopeptide repeat domain 39B (Ttc39b) is downregulated in the non-occluded MCAs and upregulated in the occluded MCAs when compared with control MCAs, and (2) FK506 binding protein 3 (Fkbp3) is upregulated in the non-occluded MCAs and downregulated in the occluded MCAs when compared with control MCAs