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Table 3 Gene enrichment analysis for the occluded and non-occluded middle cerebral arteries (MCAs) from female rats. Selected overlapping overrepresented biological process gene ontology (GO) terms identified for both the occluded and non-occluded MCAs when compared with control MCAs

From: Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats – comparisons with males

Biological process, GO ID

Occluded MCAs

Non-occluded MCAs

Freq in Geneset

FEa

P-value

Freq in Geneset

FEa

P-value

Response to oxygen-containing compound, GO:1901700

315

1.9

5.06E-22

49

2.8

4.39E-07

Regulation of cell communication, GO:0010646

455

1.7

1.52E-21

61

2.1

1.61E-04

Response to stress, GO:0006950

445

1.7

3.11E-21

63

2.2

7.74E-06

Regulation of gene expression, GO:0010468

507

1.6

3.98E-20

64

1.8

4.13E-03

Response to cytokine, GO:0034097

171

2.3

5.38E-17

24

3.0

0.02

Response to lipid, GO:0033993

193

1.9

2.37E-12

35

3.3

7.56E-06

Regulation of transcription by RNA polymerase II, GO:0006357

281

1.7

4.94E-12

44

2.5

2.78E-04

Regulation of transcription, DNA-templated, GO:0006355

374

1.5

4.92E-11

56

2.1

4.04E-04

Tissue development, GO:0009888

245

1.7

1.25E-10

40

2.6

2.61E-04

Positive regulation of intracellular signal transduction, GO:1902533

153

1.9

3.26E-08

25

2.9

0.03

Transmembrane receptor protein tyrosine kinase signaling pathway, GO:0007169

69

2.4

9.91E-06

14

4.5

0.04

  1. aFE: Fold enrichment