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Table 4 Overlapping differentially expressed genes found for each of the experimental tMCAO stroke groups (Fig. 9). Thirty-two differentially expressed genes found for each of the following experimental stroke groups (tMCAO [transient middle cerebral artery occlusion] stroke models): Occluded versus non-occluded middle cerebral arteries (MCAs) from Wistar-Kyoto (WKY) male rats (results from Grell et al. [20]), (ii) occluded MCAs vs control MCAs from Wistar female rats, and (iii) non-occluded MCAs vs control MCAs from Wistar female rats. The number of overlapping genes can be found in Fig. 9

From: Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats – comparisons with males

Gene symbol

Gene description

WKY male rats (occluded vs non-occluded MCAs)

Wistar female rats (occluded MCAs vs control MCAs)

Wistar female rats (non-occluded MCAs vs control MCAs)

P-value

Fold change

P-value

Fold change

P-value

Fold change

A2m

Alpha-2-macroglobulin

1.95E-05

4.99

6.50E-08

17.90

1.83E-03

2.19

Acsl1

Acyl-CoA synthetase long-chain family member 1

1.94E-04

−1.68

8.00E-04

−2.40

1.23E-03

− 1.42

Adamts9

A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

3.38E-04

2.29

1.17E-05

7.83

5.14E-04

1.64

Asns

Asparagine synthetase

1.44E-05

2.52

3.93E-06

8.16

1.92E-04

1.64

Bcl3

B-cell CLL/lymphoma 3

6.42E-03

3.03

5.86E-06

8.01

2.17E-05

1.92

Bri3

Brain protein I3

1.25E-04

−1.58

1.66E-04

−2.56

6.95E-04

− 1.29

Cd200

Cd200 molecule

2.68E-03

1.80

8.15E-08

3.30

1.72E-05

1.86

Ifitm3

Interferon induced transmembrane protein 3

2.43E-05

2.02

2.18E-07

2.98

3.77E-04

1.48

Itga5

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

1.57E-03

2.03

3.71E-04

4.37

1.13E-04

1.61

Lcn2

Lipocalin 2

6.31E-04

3.47

3.60E-03

12.39

1.28E-02

8.36

Litaf

Lipopolysaccharide-induced TNF factor

3.07E-04

2.32

3.30E-06

6.81

4.53E-04

1.32

Manba

Mannosidase, beta A, lysosomal

8.27E-05

−1.52

8.37E-05

−2.03

7.56E-04

−1.41

Map 3 k6

Mitogen-activated protein kinase kinase kinase 6

4.36E-04

1.86

1.45E-06

4.43

1.00E-05

2.43

Mt1a

Metallothionein 1a

3.02E-03

2.40

6.04E-08

11.14

1.11E-04

2.79

Mt2A

Metallothionein 2A

3.61E-03

3.05

4.14E-07

28.56

2.56E-07

9.03

Mtss1l

Metastasis suppressor 1-like

2.13E-03

−1.68

3.25E-07

−2.88

1.86E-03

−1.43

Nampt

Nicotinamide phosphoribosyltransferase

3.10E-04

1.65

2.82E-07

2.54

4.63E-07

1.88

Osmr

Oncostatin M receptor

1.07E-03

2.55

3.35E-09

9.09

4.70E-06

2.41

Pfkm

Phosphofructokinase, muscle

1.70E-04

−1.67

4.68E-05

−2.16

1.37E-04

−1.29

Pla1a

Phospholipase A1 member A

1.21E-05

2.58

1.48E-04

4.41

1.87E-03

1.85

Plxdc2

Plexin domain containing 2

1.40E-04

−1.43

2.02E-05

−1.95

2.04E-05

−1.35

Ptpn2

Protein tyrosine phosphatase, non-receptor type 2

2.89E-03

2.03

1.41E-05

5.89

6.99E-05

1.48

RGD1564664

Similar to LOC387763 protein

6.82E-04

2.59

4.79E-09

6.07

1.64E-04

1.66

Runx1

Runt-related transcription factor 1

1.24E-03

2.60

1.46E-05

4.59

1.93E-05

1.75

Sbno2

Strawberry notch homolog 2 (Drosophila)

3.03E-03

2.45

5.29E-06

6.87

2.90E-05

2.60

Slc29a2

Solute carrier family 29 (nucleoside transporters), member 2

1.74E-04

2.17

2.29E-04

2.85

6.60E-04

1.38

Sod2

Superoxide dismutase 2, mitochondrial

3.33E-06

2.72

9.45E-06

4.50

3.26E-03

1.62

Spp1

Secreted phosphoprotein 1

4.45E-04

4.82

2.54E-08

15.39

1.22E-04

2.14

Tgfbi

Transforming growth factor, beta induced

2.36E-05

−1.55

2.37E-04

−1.54

7.57E-04

−1.42

Tmem51

Transmembrane protein 51

3.39E-04

−1.65

1.26E-07

−2.80

1.26E-04

−1.42

Tnfrsf1a

Tumor necrosis factor receptor superfamily, member 1a

3.12E-04

1.73

5.77E-07

3.30

2.53E-05

1.49

Uap1

UDP-N-acteylglucosamine pyrophosphorylase 1

1.29E-03

1.72

4.24E-05

4.60

9.51E-04

1.61